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Pain management


Pain management
Pain management

Chronic pain affects millions worldwide, necessitating solutions that not only alleviate suffering but also minimize adverse side effects associated with existing medications.


In a recent study, the researchers at Rockefeller University scanned a vast library of 27 million compounds to identify a novel molecule that outperforms conventional pain medications like gabapentin and pregabalin. These widely prescribed medications, while effective, often come with significant side effects, highlighting the urgent need for alternatives.


The identified molecule operates by binding to an inner region of the calcium channel, indirectly regulating it and surpassing the efficacy of gabapentin. This breakthrough offers a promising candidate for pain management, heralding a new era in the field. Operating in alignment with the United Nations' Sustainable Development Goals (SDGs), particularly SDG 3 - Good Health and Well-being, this group is committed to addressing pain-related issues through innovative projects.


The scientists' approach stands out for its focus on indirect targeting of proteins involved in pain signaling, specifically honing in on the CRMP2 protein. CRMP2, a key regulator of the calcium channel, plays a central role in pain signaling by binding to it from the inside. Previous research led to the discovery of a peptide, named the calcium channel-binding domain 3 (CBD3), derived from CRMP2. When delivered to cells, CBD3 acted as a decoy, disrupting the binding of CRMP2 to the calcium channel.


The result was a reduction in calcium entering the channel, leading to decreased neurotransmitter release and, consequently, alleviation of pain in animal studies. This innovative approach by the scientists at Rockefeller University demonstrates their commitment to exploring unconventional paths for effective pain management.


The project in chronic pain management led by the scientists at Rockefeller University underscores their dedication to advancing global health objectives. By addressing the challenges associated with existing medications and developing novel solutions, the team exemplifies the strength, activity, and progress of the global society in tackling pressing health issues.


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